• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.
    公开号:SU751323A3
    申请号:SU772469960
    申请日:1977-04-18
    公开日:1980-07-23
    发明作者:Рагху Сивараман；Кентаро Хоффманн Артур；Синг Балвонт
    申请人:Американ Цианамида Компани (Фирма)；
    IPC主号:
    专利说明:

    1- (2-Methoxyethyl) -4- (m-methoxyphenyl) and Av1Dazolidin-2-thione
    1- (2-Methoxyethyl) -4- (m-chlorophenyl) imidazolidin-2-thione
    1- (2-Methoxyethyl) -4- (m-bromophenyl) imidazolidin-2-thione
    1- (2-Methoxyethyl) -4- (m-trifluoromethylphenylimidazolidin-2-thione
    1- (2-Methoxyethyl) -4- (p-chlorophenyl) imidazolidin-2-thione
    b- (m-methoxyphenyl) -2, 3,5,6-tetrahydroimidazo 2,1-b thiazoloxalate
    6- (m-Chlorophenyl) -2, 3.5, b-tetrahydroimidazo 2,1-β2 thiazole hydrochloride
    b- (m-bromophenyl) -2,3, 5, b-tetrahydroimidazo 2,1-b thiazole hydrochloride
    6- (m-Trifluoromethylphenyl) -2,3,5,6-tetrahydroimidazo 2, l-bj thiazole-hydrochloride 1716- (p-Chlorophenyl) -2,3, 5,6-tetrahydroimidazo 2,1-b-thiazolok192 salat
    权利要求:
    Claims (1)
    [1]
    Claim
    The method of obtaining substituted 2,3,5, b-tetrahydroimidazolo [2,1-bJ thiazole, General formula
    H where R is phenyl 45 or phenyl substituted with 1-2 alkoxy groups Cj-C ^, halogen or trifluoromethyl;
    Y is an anion, such as Ct, HC2O4, or its salts, 50 characterized in that the substituted imidazolidinedione of the general formula where ! <has the indicated meanings, • is heated with a compound of the general formula
    HY, where Y has the indicated meanings, in a solvent at 0-200 ° C, with the isolation of the target product in free form or in the form of a salt.
    类似技术:
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    同族专利:
    公开号 | 公开日
    US4090025A|1978-05-16|
    ZA771528B|1978-01-25|
    BE853919A|1977-10-25|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3726894A|1971-06-24|1973-04-10|American Cyanamid Co|The compound 1--4-phenyl-2-imidazolidinethione|US4310672A|1976-04-26|1982-01-12|American Cyanamid Co.|Synthesis of intermediates for tetramisole, levamisole and their derivatives|
    CA1135270A|1978-11-06|1982-11-09|American Cyanamid Company|Processes for the preparation oftetramisole and novel intermediates|
    EP0010851B1|1978-11-06|1982-08-04|American Cyanamid Company|Process for the preparation of tetramisole|
    US4216331A|1979-02-06|1980-08-05|American Cyanamid Company|Use of chiral rhodium-diphosphine catalyst capable of catalytic reduction of a tetramisole precursor to give a significant excess of the desired S- isomer levamisole|
    DE2934746A1|1979-08-28|1981-03-19|A. Nattermann & Cie GmbH, 5000 Köln|OXOIMIDAZOLINAL ACAN ACIDS, THEIR SALTS AND ESTERS AND METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME|
    US5516647A|1993-11-05|1996-05-14|Abbott Laboratories|Compounds useful as alkaline phosphatase inhibitors and therapeutic agents|
    CN101585812B|2009-06-17|2011-05-25|浙江工业大学|Preparation method oftype thioic imidazolone compound|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US68031176A| true| 1976-04-26|1976-04-26|
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